Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors

Sustained Activity of Metabotropic Glutamate Receptor: Homer, Arrestin, and Beyond

When activated, metabotropic glutamate receptors (mGlus) exert long-lasting changes within the glutamatergic synapses. One mechanism is a tonic effect of downstream signal transduction pathways via sustained activation of mGlu itself. Like many other G protein-coupled receptors (GPCRs), mGlu can exist in a constitutively active state, which persists agonist independently. In this paper, we revi...

Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons.

Group I metabotropic glutamate receptors (mGluR1 and mGluR5) are important neuronal mediators of postsynaptic signaling that influence synaptic strength, plasticity, and other factors. Regulation of group I mGluR localization and function by Homer proteins appears to be a viable means for neurons to fine-tune these processes. The presence of different Homer isoforms can act as a switch to repri...

Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.

BACKGROUND Glutamatergic transmission is one of the main components of the stress response; nevertheless, its role in the emotional stress sequelae is not known. Here, we investigated whether interactions between group I metabotropic glutamate receptors (metabotropic glutamate receptor 1 and metabotropic glutamate receptor 5 [mGluR5]) and Homer proteins mediate the delayed and persistent enhanc...

Title : Metabotropic glutamate receptor 5 : a candidate

Background: Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the pathophysiology of these disorders remains unknown. Discussion: The majority of studies in the schizophrenia post-mortem brain indicate that total mGluR5 expression is unalter...

A novel metabotropic glutamate receptor 5